Ayahuasca is the sequel to The Uninvited Traveler.

Lou hates his job and decides to head south and create a new life. While trying to get his old girlfriend, Jay, to flee with him, they are car jacked by Thomas, an alien seeking asylum for himself and his people. Their journey south takes them to Florida in search of a retired NASA scientist, the jungles of South America, and Bermuda. In this book, they return to Peru, having become entangled with a drug smuggler who promises them a big paycheck. Lou and Jay's involvement with Ricardo, the smuggler, almost costs them their lives.